Join Facebook to connect with William Bentley and others you may know. Biochemical Science & Technology, National Taiwan University, Taiwan
stream IBBR is a unique entity in that it fosters integrated cross-disciplinary team approaches to scientific discovery, translational development and education, creating commercialization relationships and initiatives that serve the expanding economic base of biosciences and technology in the state of Maryland and across the country. Songhee Kim, Ph.D., 2005, KIST, Seoul, S. Korea All cells sense and respond to their environment. Recent interests are on deciphering and manipulating signal transduction pathways, including those of bacterial communication networks, for altering cell phenotype. We have discovered that redox provides an almost unique capability for this information transfer as it is a fundamental communication modality within biology and is directly accessed via electronics. Email: bentley@umd.edu Web site: www.bentley.umd.edu WILLIAM E. BENTLEY is the Robert E. Fischell Distinguished Chair of Engineering and was the founding Chair of the Fischell Department of Bioengineering. The National Institute for Innovation of Manufacturing Biopharmaceuticals (NIIMBL) will be the 11th Manufacturing USA Institute, and includes the University of Maryland, College Park and the University of Maryland, Baltimore.
Robert E. Fischell Distinguished Professor, Autonomous coordination of cell subpopulations highlighted in, Redox information may hold key to rapidly diagnosing disease, $250 million dollar investment will advance leadership in pharmaceutical manufacturing, New building to serve as hub for human health innovation in the state of Maryland, The Fischell Department of Bioengineering at the A. James Clark School of Engineering, University of Maryland, Biomolecular and Metabolic Engineering Laboratory, Institute for Bioscience and Biotechnology Research, Researchers Aim to Sterilize N95 Masks for Reuse, Stephens Wins First Place Dean's Doctoral Student Research Award, 2020 Dean's Doctoral Student Research Awards, Rapidly evolving ‘smart marble’ sensors hold promise for monitoring pharmaceutical industry bioreactors and beyond, Adams' Synthetic Biology Tools for Military Relevant Microbes, BIOE Capstone Class Virtually Presents 24 Novel Projects, UMD Researchers Tap CRISPR Technology to Connect Biology, Electronics, Spurring research group creativity in the time of COVID-19, Researchers Develop Rapid Deployment Mask, Researchers Work to Develop Custom Conformal N95 Respirators, NCC-PDI, MedTech Innovator Accepting Pitches for 2020 Competition, Institute Hosts AMBIC December Conference, Unveils New Research, Accepting Fischell Institute/IBBR Travel Fellowship Applications, UMD Researchers Develop Technique to Advance Cell-Based Systems, Ghodssi Receives Senior Faculty Outstanding Research Award, DoD Awards $1M to Develop Portable Medical Sensors, BIOE Capstone Class Presents 20 Novel Projects, Four BIOE Students Named NSF Graduate Research Fellows, State and University Officials Celebrate Launch of Biomedical Device Institute, FDA Awards $10 Million to Support Regulatory Science, Medical Device Initiatives Co-led by Clark School, FDA Awards $5 Million to Pediatric Device Consortium, M-CERSI Cooperative Agreement Grant Renewed by Food and Drug Administration, NSF grant for Ghodssi, Bentley furthers research of flexible devices to combat biofilms, ‘Smart Marbles’ hold promise for better outcomes from bioreactors, Bridging the Gap between Microelectronics, Biological Systems, BIOE Capstone 2018: Projects Focus on Point of Care Diagnostics, Sickle Cell Disease, Neonatal Care, and More, New Findings Demonstrate How the Food We Eat Affects Biochemical Signals in the Gut, UMD Welcomes East China University of Science and Technology, UMD Hosts Materials Genome Initiative Principal Investigator Meeting, New microsystems detect, treat bacterial biofilms that cause post-operative infections, Ghodssi, Bentley receive NSF EAGER grant to develop ingestible capsules for medical diagnosis, Researchers Engineer Bacteria to Hunt Down Pathogens in the Gut, Government, Industry, Academia Representatives Collaborate to Advance Medical Device Innovation in Maryland, UMD Researchers Make Strides in Schizophrenia Diagnosis Research, BIOE, IBBR Researchers Develop Electrogenetic Device for Activating Gene Expression via Electrodes, UMD Key Partner in New National Institute for Innovation of Manufacturing Biopharmaceuticals, Bentley Named Distinguished University Professor, BioE Capstone 2016: New Projects Focus on Improved Healthcare for Underserved Communities, Pediatric Patients, and More, Fischell Receives National Medal of Technology and Innovation, NCC-PDI Pediatric Device Competition Now Accepting Proposals From Medical Device Innovators, BioE Researchers Develop Nano-guided Cell Networks as Conveyors of Molecular Communication, Fisher Named Chair of the Fischell Department of Bioengineering, BioE Capstone 2015: New Projects Focus on Sensorineural Hearing Loss, Injury Rehabilitation, and More, Bentley Featured in Science Update Podcast, UMD Patents Compounds that Inhibit Biofilm Formation and Persistence, Maryland inventors issued US Patent for compounds that fight biofilms, Second Annual Pediatric Device Innovation Competition Awards $250,000, University of Maryland Breaks Ground for A. James Clark Hall, UMD Researchers Bridge Gap between Microelectronics, Biological Systems, UMD, GBSI Partner to Advance Antibody Standards, International research partnership leads to major publication on controlling living cells with artificial cells, BioE Capstone 2014: New Projects Focus on Cardiological Health, Surgical Tools and More, University of Maryland Baltimore & College Park Campuses To Offer Joint M.D./Ph.D.
We may even be in a position to create âsmartâ devices that interrogate biology and take action when needed. Delia M. Ramirez Leon, Ph.D., 1995, U.S. Patent Office, VA Kelvin Lee (University of Delware), Bill Bentley (UMD BIOE), Steve Cramer (Rensselaer Polytechnic Institute), Jon Dordick (Rensselaer Polytechnic Institute), Mike Betenbaugh (Johns Hopkins University), and Stacy Springs (Massachusetts Institute of Technology). Electronic actuation of the native transcriptional regulator SoxR and transcription from the PsoxS promoter allows cell response that is quick, reversible and dependent on the amplitude and frequency of the imposed electronic signals. Previous Education: B.Tech. In our case, quorum sensing and bacterial communication (and even cross-Kingdom signaling) serves as a wonderful test bed for listening in on biology. Rohan Fernandes, Ph.D., 2008, Asst. Tracey R. Pulliam-Holoman, Ph.D., formerly Asst. This showed for the first time that one can electrically connect to and control biological behaviorâas our signal molecule generated and controlled on chip determines behavioral phenotype at the population level. Finally, because we have exploited signaling pathways to control individual and groups of cells, we engineered bacteria to seek out and kill pathogens, namely, Pseudomonas aeruginosa, in the GI tract of mice. Liu, Y., J. L. Terrell, C.-Y. “I'm particularly excited that this will help forge links between the universities, NIST, and the Food and Drug Administration, all of which serve as vital Maryland institutions with key roles in biopharmaceuticals manufacturing.”, “To develop a delivery system, one must develop a formulation, downstream processing, and advanced characterization of the protein molecules in the product," says, “IBBR adds an important dimension to the NIIMBL team of investigators with its state-of-the-art biomanufacturing facility, capable of Good Manufacturing Practices (GMP) biotherapeutics production,” said, A. James Clark School of Engineering, University of Maryland, Institute for Bioscience and Biotechnology Research (IBBR), University of Maryland Center of Excellence in Regulatory Science and Innovation (M-CERSI). We show that the biochemical output of the system correlates with the electrical input charge, which suggests that electrical inputs could be used to control complex on-chip biological processes. The biology material will focus on: distinguishing engineering from biological science, principles form the sciences applicable to biology, typical biological responses to environmental stimuli, scaling of biological responses, and different means to utilize living entities. :�/��DZ.�1H�ܔ���#���g�{�W�b��ؽ� William E. Bentley is the Robert E. Fischell Distinguished Professor of Engineering and founding Director of the Fischell Institute for Biomedical Devices located in the A. James Clark School of Engineering at the University of Maryland.
The biopharmaceutical field has a negative unemployment rate, with more jobs available than there are qualified workers. Recognizes an individual's outstanding chemical engineering contribution in the food, pharmaceutical and/or bioengineering field, of fundamental nature and/or of practical significance to industry and industrial practice. Previous efforts to control cellular behaviour have largely relied upon various forms of genetic engineering. In order to control the behavior of bacteria present at the surface of human epithelial cells, we have created a biological ânanofactoryâ construct that âcoatsâ the epithelial cells and âactivatesâ the surface to produce the bacterial quorum sensing signaling molecule, autoinducer-2 (AI-2). Liba, B. D., Kim, E., Martin, A. N., Liu, Y., Wu, H. C., Tsao, C. Y., Quan, D. N., Cheng, Y., Servinsky, M. D., Carter, K. K., Jee, K. J., Terrell, J. L., Zargar, A., Rubloff, G. W., Payne, G. F., Valdes, J. J., and, Terrell, J.L., Gordonov, T., Cheng, Y., Wu, H.C., Sampey, D., Luo, X., Tsao, C.Y., Ghodssi, R., Rubloff, G.W., Payne, G.F., and. Tsu-shun Lee, Ph.D., 1997, Sanofi Pasteur, Swiftwater, PA Kelvin Lee (University of Delware), Bill Bentley (UMD BIOE), Steve Cramer (Rensselaer Polytechnic Institute), Jon Dordick (Rensselaer Polytechnic Institute), Mike Betenbaugh (Johns Hopkins University), and Stacy Springs (Massachusetts Institute of Technology). NIIMBL has also received strong support from Montgomery County, BioHealth Innovation, and many Maryland companies, associations, and community colleges such as Montgomery and Baltimore Community College. “I was proud to join my colleagues in sending a letter supporting this application for a grant to establish the National Institute for Innovation in Manufacturing Biopharmaceuticals. The institute will also help ensure the nation can rapidly scale up manufacturing of these advanced treatments to respond to pandemics and other biological threats, and eliminate drug shortages that can result from quality control issues in manufacturing. Professor, Dept. There is a continuing quest to precisely fabricate soft matter for emerging opportunities in the medical and life sciences. We are engaged in a multidisciplinary effort to create systems that serve to bridge the communication gap between biology and electronic microfabricated devices. Nimish G. Dalal, Ph.D., 2001, Bristol Myers Squibb, Syracuse, NY The biological system can be electrically tuned using a natural redox molecule, and its biochemical response is shown to provide the signalling cues to drive bacterial population behaviour. A member whose efforts on behalf of the advancement of science or its applications are scientifically or socially distinguished and who has been a continuous member for the four year period leading up to the year of nomination, may, by virtue of such meritorious contribution be elected a Fellow by the Council.
We believe these initial studies indicate broad possibilities for enlisting electrochemistry and signal processing to acquire âsystems levelâ redox information from biology. The process takes about 6âh, irrespective of quorum level. We employ Natureâs second most abundant biopolymer, chitosan, to serve as a âsmartâ stimuli-responsive interface. Maryland Commerce was pleased to provide strong support for the state’s proposal for NIIMBL.". Interestingly, the bound D5P and D8P molecules are not the diketone forms but rather hydrated, and the hydrated moiety forms important H-bonds with the carboxylate of D243. (Tshirhart et al., Nature Comm., 2017). She has presented her work at the ACS meeting. Elected Fellow, American Institute for Medical and Biological Engineering. I’m confident the institute will ensure Maryland plays a significant role in advancing biopharmaceutical manufacturing in the years to come.”. For more information, please visit Professor Bentley's web site. While engineered cells have transmitted molecular information to electronic devices, the potential for bidirectional communication stands largely untapped. University of Maryland, Robert E. Fischell Institute for Biomedical Devices, University of Maryland, Fischell Department of Bioengineering, University of Maryland, Glenn L. Martin Institute of Technology, University of Maryland, Department of Chemical and Biomolecular Engineering, Master of Engineering in Chemical Engineering, Bachelor of Science in Chemical Engineering. Here, we describe the intentional assembly of quantized quorums. NIIMBL researchers will also work with the University of Maryland Center of Excellence in Regulatory Science and Innovation (M-CERSI), the first federally-supported research center between the U.S. Food and Drug Administration (FDA) and the University of Maryland’s two preeminent research campuses. The D5P-binding flipped out F124 of the binding pocket, and resulted in the disruption of the dimeric interface-1 by unfolding the α7 segment. She is co-advised by Prof. Bill Bentley from BioE. This notion of synthetic biology is different than small molecule generation â the more common objective of synthetic biology. (Hwang et al., Nature Comm., 2017). William E. Bentley is the Robert E. Fischell Distinguished Chair of Engineering and the Inaugural Director of the Robert E. Fischell Institute for Biomedical Devices. We electronically amplify bacterial quorum sensing (QS) signaling by activating LasI, the autoinducer-1 synthase. We report that HPr, a phosphocarrier protein central to the sugar phosphotransferase system of Escherichia coli, copurifies with LsrK. The institute will focus on bringing safe drugs to market faster and on developing workforce training. In addition, TumbleScore produces a ârose graphâ visualization of bacterial paths. Because the autoinducer AI-2 is secreted by a wide variety of bacterial species, its âperceptionâ cues bacterial behavior. A team of more than 150 companies, educational institutions, nonprofits and state governments will operate NIIMBL under a newly formed nonprofit. “UMSOP is perfectly positioned to conduct these types of studies through its nanotechnology center, its industrial pharmaceutics lab, and its mass spectrometry center.”.
Presentation of techniques for characterizing and manipulating non-linear biochemical reaction networks.
We further develop a simple mathematical model that enables cell and system design for autonomous closed-loop control of population trajectories. In our view, the cells themselves can be the functioning products of synthetic biology in that they can recognize, compute, actuate, and deliver, all in a programmed manner. Then, based on calculated feature density, these cells expressed marker proteins to indicate phenotypic response. Today, biopharmaceuticals are a mainstay for health care, and include therapies such as vaccines, treatments for cancer and autoimmune diseases, and emerging drugs for cell and gene therapies.
This molecule, in turn, actuated gene expression in neighboring cells. We exploited redox signaling, but actuated in a reversible manner expression of several genes in E. coli, including those that synthesize native signaling molecule, AI-1.
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